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Building on the base of the existing telescopes of the Event Horizon Telescope (EHT) and ALMA, the next-generation EHT (ngEHT) aspires to deploy ∼10 more stations. The ngEHT targets an angular resolution of ∼15 microarcseconds. This resolution is achieved using Very Long Baseline Interferometry (VLBI) at the shortest radio wavelengths ∼1 mm. The Submillimeter Array (SMA) is both a standalone radio interferometer and a station of the EHT and will conduct observations together with the new ngEHT stations. The future EHT + ngEHT array requires a dedicated correlator to process massive amounts of data. The current correlator-beamformer (CBF) of the SMA would also benefit from an upgrade, to expand the SMA’s bandwidth and also match the EHT + ngEHT observations. The two correlators share the same basic architecture, so that the development time can be reduced using common technology for both applications. This paper explores the prospects of using Tensor Core Graphics Processing Units (TC GPU) as the primary digital signal processing (DSP) engine. This paper describes the architecture, aspects of the detailed design, and approaches to performance optimization of a CBF using the “FX” approach. We describe some of the benefits and challenges of the TC GPU approach. 

Supramolecular nanocages with inner cavities have attracted increasing attention due to their fascinating molecular aesthetics and vast number of potential applications. Even though a wide array of discrete supramolecular cages with precisely designed sizes and shapes have been established, the controlled assembly of higher-order supramolecular frameworks from discrete molecular entities still represents a formidable challenge. In this work, a novel metallo-organic cage [Zn12L4] was assembled based on a triphenylene-cored hexapod terpyridine ligand. Synchotron X-ray analysis revealed a pair of enantiomeric cages in the crystal with flexible ligands twisted clockwise or anticlockwise due to steric hindrance in the structure. Interestingly, due to the strong π–π intermolecular interaction between triphenylene units, a controlled hierarchical packing of sphere-like cages in the crystal was established having a sparse packing mode with huge channels of around 3.6 nm diameter. This research sheds light on the design of strong π–π interactions in supramolecular hierarchical packing and materials science. 

Potassium (K⁺) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K⁺channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of glutamatergic neurons was impaired in the neocortices of KCNB1 null mice. Migratory defects persisted into the adult brains, along with disrupted morphology and synaptic connectivity. Mice developed seizure phenotype, anxiety, and compulsive behavior. To determine whether defective KCNB1 can give rise to developmental channelopathy, we constructed Knock In (KI) mice, harboring the gene variantKcnb1^R312H(R312H mice) found in children with developmental and epileptic encephalopathies (DEEs). The R312H mice exhibited a similar phenotype to the null mice. Wild type (WT) and R312H KCNB1 channels made complexes with integrins α5β5 (Integrin_K⁺channel_Complexes, IKCs), whose biochemical signaling was impaired in R312H brains. Treatment with Angiotensin II in vitro, an agonist of Focal Adhesion kinase, a key component of IKC signaling machinery, corrected the neuronal abnormalities. Thus, a genetic mutation in a K⁺channel induces severe neuromorphological abnormalities through non-conducting mechanisms, that can be rescued by pharmacological intervention. This underscores a previously unknown role of IKCs as key players in neuronal development, and implicate developmental channelopathies in the etiology of DEEs.

 

ABSTRACT The Mw 7.2 Nippes, Haiti, earthquake occurred on 14 August 2021 in Haiti’s southwest peninsula and in the midst of significant social, economic, and political crises. A hybrid reconnaissance mission (i.e., combined remote and field investigation) was coordinated to document damage to the built environment after the event. This article evaluates two ground-motion records available in Haiti in the context of the geology of the region and known areas with significant damage, such as Les Cayes. We also present a new map of time-averaged shear-wave velocity values to 30 m depth (VS30) for Les Cayes and Port-au-Prince based on the geostatistical approach of kriging and accounting for region-specific geology proxies and field measurements of VS30. Case studies of ground failure observations, including landslides and liquefaction triggering, are described as well as the intersection of social and engineering observations. Maps depicting this important intersection are provided to facilitate the assessment of how natural hazards and social conflicts have influenced the vulnerability of Haiti’s population to earthquakes. 

Four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants predominated in the United States since 2021. Understanding disease severity related to different SARS-CoV-2 variants remains limited.

Viral genome analysis was performed on SARS-CoV-2 clinical isolates circulating March 2021 through March 2022 in Cleveland, Ohio. Major variants were correlated with disease severity and patient outcomes.

In total 2779 patients identified with either Alpha (n = 1153), Gamma (n = 122), Delta (n = 808), or Omicron variants (n = 696) were selected for analysis. No difference in frequency of hospitalization, intensive care unit (ICU) admission, and death were found among Alpha, Gamma, and Delta variants. However, patients with Omicron infection were significantly less likely to be admitted to the hospital, require oxygen, or admission to the ICU (χ2 = 12.8, P < .001; χ2 = 21.6, P < .002; χ2 = 9.6, P = .01, respectively). In patients whose vaccination status was known, a substantial number had breakthrough infections with Delta or Omicron variants (218/808 [26.9%] and 513/696 [73.7%], respectively). In breakthrough infections, hospitalization rate was similar regardless of variant by multivariate analysis. No difference in disease severity was identified between Omicron subvariants BA.1 and BA.2.

Disease severity associated with Alpha, Gamma, and Delta variants is comparable while Omicron infections are significantly less severe. Breakthrough disease is significantly more common in patients with Omicron infection.

 

Magnesium (Mg) is an essential metal for chlorophyll biosynthesis and other metabolic processes in plant cells. Mg is largely stored in the vacuole of various cell types and remobilized to meet cytoplasmic demand. However, the transport proteins responsible for mobilizing vacuolar Mg2+ remain unknown. Here, we identified two Arabidopsis (Arabidopsis thaliana) Mg2+ transporters (MAGNESIUM TRANSPORTER 1 and 2; MGT1 and MGT2) that facilitate Mg2+ mobilization from the vacuole, especially when external Mg supply is limited. In addition to a high degree of sequence similarity, MGT1 and MGT2 exhibited overlapping expression patterns in Arabidopsis tissues, implying functional redundancy. Indeed, the mgt1 mgt2 double mutant, but not mgt1 and mgt2 single mutants, showed exaggerated growth defects as compared to the wild type under low-Mg conditions, in accord with higher expression levels of Mg-starvation gene markers in the double mutant. However, overall Mg level was also higher in mgt1 mgt2, suggesting a defect in Mg2+ remobilization in response to Mg deficiency. Consistently, MGT1 and MGT2 localized to the tonoplast and rescued the yeast (Saccharomyces cerevisiae) mnr2Δ (manganese resistance 2) mutant strain lacking the vacuolar Mg2+ efflux transporter. In addition, disruption of MGT1 and MGT2 suppressed high-Mg sensitivity of calcineurin B-like 2 and 3 (cbl2 cbl3), a mutant defective in vacuolar Mg2+ sequestration, suggesting that vacuolar Mg2+ influx and efflux processes are antagonistic in a physiological context. We further crossed mgt1 mgt2 with mgt6, which lacks a plasma membrane MGT member involved in Mg2+ uptake, and found that the triple mutant was more sensitive to low-Mg conditions than either mgt1 mgt2 or mgt6. Hence, Mg2+ uptake (via MGT6) and vacuolar remobilization (through MGT1 and MGT2) work synergistically to achieve Mg2+ homeostasis in plants, especially under low-Mg supply in the environment.